3571.18 - Toxicology
A) Admitted to the bachelor program in biology at the University of the Faroe Islands, and following the normal study progression or B) Students following single courses need to have sufficient background in general and organic chemistry, biochemistry, cell and molecular biology, genetics and basic physiology like: 3512 General and inorganic chemistry; 3513 Organic chemistry; 3514 Biochemistry; 3518 Cell and molecular biology I; 3516 Genetics and 3813 Human physiology.
To provide the students with basic knowledge of toxicology and the many facets of the discipline, especially the principles and mechanisms, the disposition of toxicants and target organ and non-organ directed toxicity.
Mechanisms: cellular, biochemical and molecular mechanisms. Disposition of toxicants: absorption, distribution, and excretion of toxicants. Biotransformation of xenobiotics. Chemical carcinogenesis. Genetic toxicology. Developmental Toxicology. Toxic Responses of selected organs (Liver, Kidney and the Nervous System)
Learning and teaching approaches
Lectures. Problem solving, discussions, student presentations, and/or other tasks. Some tasks may be obligatory
On completion of the course, the successful student should be able to: 1. Describe the different delivery mechanisms of the toxicant from the site of exposure to the target. 2. Describe the different reaction types when toxicants react with the target molecule. 3. Describe how toxicant induces cellular dysfunction/dysregulation. 4. Describe mechanisms of molecular and cellular repair with special emphasis on DNA repair and the consequences when repair fails. 5. Explain cellular transport of toxicants. 6. Give an overview of different absorption routes of toxicants in the body. 7. Briefly describe the distribution of toxicants in the body. 8. Briefly describe the different excretion routes of toxicants in the body. 9. Describe in considerable details the principles of xenobiotic biotransformation. 10. Describe in considerable details the hydrolysis, reduction, oxidation and conjugation of xenobiotics. 11. Describe principles and mechanisms of cellular and molecular chemical carcinogenesis. 12. Describe briefly the principles, mechanisms and pathogenesis of maternal and developmental toxicology. 13. Describe mechanisms and types of toxicant induced injuries on some selected organs (liver, kidney and nervous system). 14. Connect and combine information from different parts of the present curriculum. 15. Connect and combine information from the present curriculum with those of previous courses, in particular biochemistry, cell and molecular biology, and genetics.
Combination of 1) accepted obligatory tasks and 2) graded written examination. 1) The obligatory tasks must be delivered within the specified deadlines, and they must be accepted (no grading) by the instructor. 2) Four-hour written examination. No auxiliary materials allowed, except for electronic calculator. Computers/laptops are not allowed. The student may attend the ordinary exam before all obligatory tasks are accepted, but the grading will only be made valid upon acceptance. When the tasks have been accepted, they are also valid in case of reexamination. If the tasks are not accepted, a potential re-examination cannot be attended.
Curtis D. Klaassen (editor) Casarett & Doull’s Toxicology: The Basic Science of Poisons, 8th edition. Mc Graw Hill Education. 2013. Hardcover: ISBN 978-0-07-176925-9 Paperback: ISBN 978-0-8153-4455-1. Handouts.