3516.09 - General genetics and molecular biology
Course number
3516.09
Title
General genetics and molecular biology
ECTS
7.5
Purpose
To provide the students with a basic knowledge of classical and molecular genetics, including insight into heritable and acquired genetic diseases.
Content
The genetic code. Mendelian genetics. Linkage and chromosome mapping. DNA manipulation and technology. Gene regulation, gene expression and RNA processing. Development and differentiation. Mutations and DNA repair. Heritable and acquired genetic diseases. Molecular evolution. Populations genetics.
Laboratory exercize: Hemoglobin gene expression in cod. The exercize is organized as a small research project, with a first part where published sequences are collected from databanks, and these data are analyzed to achíeve a plan for how to proceed in the second part. The second part is the practical work up the actual blood samples from cod to cDNA and gDNA, amplify sequences with PCR, and subsequently obtain the DNA sequences. The students must participate both in the theoretical and practical part of the exercize. The report should be formed as a research manuscript.
Learning and teaching approaches
Lectures. Problem solving. Laboratory work and theoretical work using bioinformatic tools to (i) collect and analyze data from sequence databanks as basis for subsequent laboratory work, and (ii) analyze results from the laboratory work.
Assessment method
Written report from laboratory exercize counts 25%. Four-hour written examination. NVD computer is available. Electronic calculator allowed, otherwise no auxiliary material. The existing grade scale will be used.
Contact
Svein-Ole Mikalsen